Contrast-enhanced imaging of SPIO-labeled platelets using magnetomotive ultrasound
نویسندگان
چکیده
منابع مشابه
Magnetic and contrast properties of labeled platelets for magnetomotive optical coherence tomography.
This article introduces a new functional imaging paradigm that uses optical coherence tomography (OCT) to detect rehydrated, lyophilized platelets (RL platelets) that are in the preclinical trial stage and contain superparamagnetic iron oxides (SPIOs) approved by the U.S. Food and Drug Administration. Platelets are highly functional blood cells that detect and adhere to sites of vascular endoth...
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MRI has been used extensively to noninvasively track the location of cells labeled with superparamagnetic iron-oxide nanoparticles (SPIOs) in vivo. Typically, SPIOs are employed as a negative contrast agent which makes it difficult to differentiate labeled cells from extraneous sources of inhomogeneity and actual voids in the image. As a result, several novel approaches have been put forth to o...
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Introduction: Positive-contrast imaging of super paramagnetic iron oxide (SPIO)labeled cells avoids problems associated with negative contrast such as other signal voids and partial volume effects [1-7]. Many techniques offer 2D imaging with thick slices and long scan times. A fast 3D alternating repetition time (ATR) SSFP [8] method with reliable on-resonant suppression has recently been intro...
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We introduce a novel contrast mechanism for optical coherence tomography (OCT) whereby the optical scattering of magnetically labeled cells is modified by means of an externally applied magnetic field. This modification is made through the addition of a small electromagnet to the imaging arm of a conventional OCT interferometer. We measure the magnetomotive OCT signal by differencing pairs of a...
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2013
ISSN: 0031-9155,1361-6560
DOI: 10.1088/0031-9155/58/20/7277